Compton本身不提供图形化界面来设置自定义快捷键，通常需通过桌面环境或窗口管理器来实现，以下是不同系统的方法：
gsettings命令：打开终端，依次输入gsettings set org.gnome.settings-daemon.plugins.media-keys custom-keybindings "['/org/gnome/settings-daemon/plugins/media-keys/custom-keybindings/custom0/']"、gsettings set org.gnome.settings-daemon.plugins.media-keys.custom-keybinding:/org/gnome/settings-daemon/plugins/media-keys/custom-keybindings/custom0/ name 'Toggle Compton'、gsettings set org.gnome.settings-daemon.plugins.media-keys.custom-keybinding:/org/gnome/settings-daemon/plugins/media-keys/custom-keybindings/custom0/ command 'compton --replace'、gsettings set org.gnome.settings-daemon.plugins.media-keys.custom-keybinding:/org/gnome/settings-daemon/plugins/media-keys/custom-keybindings/custom0/ binding '<你的快捷键组合>'，将<你的快捷键组合>替换为实际想设置的组合键，如<Ctrl><Alt>C。dconf-editor：安装dconf-editor（若未安装），打开后在路径org->gnome->settings-daemon->plugins->media-keys->custom-keybindings下添加新快捷键，填写名称、命令和绑定。~/.i3/config文件，添加如bindsym $mod+Shift+T exec --no-startup-id compton --config /path/to/your/compton.conf的代码，将$mod替换为实际修饰键，/path/to/your/compton.conf替换为配置文件路径，还可设置透明度等参数，保存后重新加载i3配置。